STORIES

Vanderbilt Researchers on CBD and Epilepsy

By David Jenison on March 24, 2018

Epilepsy & Behavior recently published a new study titled "Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy," and it found that cannabidiol (CBD) appears to be effective in helping treat the neurological disorder. 

A team of researchers at the Vanderbilt University School of Medicine and the Children's Hospital at Vanderbilt studied 108 children whose treatment regimen included cannabis-derived CBD oil. The study, which also tracked concurrent use of the anticonvulsant drug clobazam, noted that one in three patients continue to have seizures when taking traditional medication. The addition of CBD made a difference. 

For the children who started taking CBD, the findings were as follows:

  • Average seizure rate had been 89 per month
  • One child suffered 675 seizures per month
  • 33 percent saw their seizures decrease by at least half
  • 14 percent were free from all seizures
  • Six percent experienced more seizures
  • Average treatment period of 1.1 years


For the children who started taking both CBD and clobazam, the findings were as follows:

  • Average seizure rate had been 372 per month
  • One child suffered 4,680 seizures per month
  • 44 percent saw their seizures decrease by at least half
  • Nine percent were free from all seizures
  • Four percent experienced more seizures
  • Average treatment period of 1.3 years


For the children who started taking clobazam, the findings were as follows:

  • Average seizure rate had been 437 per month
  • One child suffered 10,800 seizures per month
  • 38 percent saw their seizures decrease by at least half
  • 11 percent were free from all seizures
  • 16 percent experienced more seizures
  • Average treatment period of 2.5 years


The efficacy of CBD is comparable to clobazam, and taking both medications together produced the most significant drop in seizures. CBD also appeared to decrease a side effect associated with clobazam: Sedation occurred in 36 percent of the patients taking clobazam, in seven percent of the patients taking both medications and in none of the CBD-only patients. 

The patients only taking CBD also experienced more positive side effects than those only taking clobazam. These improvements included increased alertness (18.8 percent vs. 6.8), better mood (4.2 percent vs. 0), better verbal skills (10.4 percent vs. 1.4), better social interaction (6.3 percent vs. 0), improved focus (2.1 percent vs. 0), decreased aggression (4.2 percent vs. 0) and improved motor function (4.2 percent vs. 0). 

"In summary, these findings support efficacy of artisanal CBD preparations in seizure reduction with few significant side effects," concluded the researchers, who noted that CBD provided benefits with and without the concurrent use of clobazam. "The response to CBD was independent of concurrent clobazam use, although clobazam may contribute to the sedation seen with concurrent CBD use."

Treat Anxiety with CBD

How CBD Affects Anxiety

How Cannabis Affects Anxiety and Paranoia

The Anxiety Experiments

CBD Products in High-End Hotels

THC More Therapeutic Than Previously Thought

What We Need to Know about Cannabis to Maximize Medical Use

Children in British Hospices Defy Prohibition

The Traditional Wisdom on THC-CBD Interactions Might Be Wrong

Top 20 Cannabis Health Benefits Part 2

Pot Pie | Brandin LaShea Feat. Talisa Monet

GET Lucky Box Club's CBD Wellness

Cannabinoid Review: Pinene

Big Pharma Fears Cannabis Rescheduling

GO Detox because there's no time like now